At FDU: Ish Kumar, Ph.D.

Phone: 2016922340 Email: ikumar@fdu.edu Office: Dickinson Hall Room 4408

Teaching Courses:

CHEM 6752 Drug Design and Discovery

CHEM 2211 Inorganic Chemistry I

CHEM 3314 Inorganic Chemistry II

CHEM7713 Structural Inorganic Chemistry

CHEM 1203 General Chemistry Lab I

CHEM 1204 General Chemistry Lab II

Ish Kumar, Ph.D.

Assistant Professor of Chemistry, School of Natural Sciences

Research Interests
A. Bioorganic and Medicinal chemistry: Virtual Screening and evaluation of non-covalent inhibitors of clinically important enzyme targets: We are interested in how enzyme structure determines function, with a focus on novel inhibitor discovery using a combination of computational chemistry, enzyme kinetics and molecular designing.

B. Application of Biocatalysis in Organic Synthesis: Biocatalysis in the preparation of enatiomerically pure pharmaceuticals, their intermediates and fine chemicals by following approaches such as microbial screening, enzyme screening, substrate-structure screening and solvent screening.

Selected Publications:

Ish Kumar, Helen R Josephine, R. F. Pratt: Reactions of Peptidoglycan-Mimetic beta-Lactams with Penicillin-Binding Proteins in Vivo and in Membranes. ACS Chem. Biol. 2, 620-624 (2007).

Puja Shahi, Ritu Sharma, Shefali Sanger, Ish Kumar, Ravinder S. Jolly: Amyloid fibril formation via longitudinal growth of oligomers Biochemistry 46(43),7365-7373 (2007).

S.A. Adediran, Ish Kumar and R.F.Pratt: Deacylation Transition States of Bacterial DD-Peptidases Biochemistry 45(43), 13074-13082 (2006).

Puja Shahi, Ish Kumar, Ritu Sharma, Shefali Sanger and Ravinder S. Jolly: Characterization of Periplasmic Long chain Acyl-CoA thio esterase from Alcaligen faecalis FEBS Journal, 273, 2374-87 (2006).

Ish Kumar and R.F. Pratt: Transpeptidation of a specific substrate catalyzed by the Streptomyces R61 DD-peptidase: the structural basis of acyl acceptor specificity Biochemistry 44 (30), 9961-9970 (2005).

Ish Kumar and R.F. Pratt: Transpeptidation of a specific substrate catalyzed by the Streptomyces R61 DD-peptidase II: Characterization of a Chromogenic Substrate and Acyl Acceptor Design. Biochemistry 44 (30), 9971-9979 (2005).

Helen R Josephine, Ish Kumar, R.F. Pratt: The perfect pencillin? Inhibition of a bacterial DD-peptidase by peptidoglycan-mimetic ā-lactams. J.Am.Chem.Soc 126 (26), 8122-23 (2004).

B. N Singh, J. J. Lucas, G. R. Hayes, Ish Kumar, D.H. Beach, Marcel Frajbalt, R. O. Gilbert, U. Sommer, C.E Costello: Trichomonas foetus Parasite Induces Apoptotic Cell Death in Bovine Host Cells in Vitro Infection and Immunity, 72(7), 4151-4158 (2004).

Ish Kumar and Ravinder S. Jolly: A Thioesterase for Chemoselective Hydrolysis of S-Acyl Sulfanylalkanoates Org. Lett. 3 (2), 283-285 (2001.

Ish Kumar, Kavita Manju and Ravinder S. Jolly: A New Biocatalyst for the Preparation of Enantiomerically Pure 2-arylpropanoic acids Tetrahedron Asymmetry, 12(10), 1431-34, (2001).

Ish Kumar and Ravinder S. Jolly: The effect of the į-methyl substituent on chemoselectivity in esterase catalyzed hydrolysis of S-acetylsulfanylalkanoates. Org. Lett. 1(2), 207-209 (1999).

Patents:

Ravinder S. Jolly, Rakesh M. Vohra and Ish Kumar: A process for the preparation of enantiomerically pure D- (-)alpha– 3-acetylthio-2-methylpropanoic acid. Indian Patent Application, filed in 1999 (1287/DEL/99); published in gazette on Dec 6th 2003 (Indian Patent No: 191586

Links of interest:

American Chemical Society
Auto dock
Small molecule database

Email address: ikumar@fdu.edu